Itraconazole works by inhibiting Cytochrome P-450 dependent enzymes, blocking the synthesis of ergosterol—an essential component of fungal cell membranes. This leads to disruption in cell wall structure, abnormal permeability, and fungal cell death.
SUBA (Super Bio-Available) technology enhances drug absorption by forming a solid dispersion in a polymer matrix. This improves solubility, providing better bioavailability compared to conventional itraconazole.
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Itracon SUBA is prescribed for a broad range of fungal infections, including:
Available strengths: 65 mg, 100 mg, 130 mg, 200 mg
Vulvovaginal candidiasis: 200 mg twice daily for 1 day (or 130 mg twice daily for 1 day)
Pityriasis versicolor: 200 mg once daily for 7 days (or 65 mg twice daily for 7 days)
Tinea corporis/cruris: 100 mg daily for 15 days OR 200 mg daily for 7 days
Tinea pedis/manuum: 100 mg daily for 30 days
Oropharyngeal candidiasis: 100 mg daily for 15 days (increase in AIDS/neutropenic patients)
Onychomycosis: Continuous—200 mg daily for 3 months OR Pulse—200 mg twice daily for 7 days, repeated after 21 days (fingernails: 2 courses; toenails: 3 courses)
Systemic infections:
Doses should be individualized based on infection type, severity, and clinical response.
Pregnancy: Contraindicated
Lactation: Not recommended
Store below 25°C, in a cool, dry place
Protect from light and moisture
Keep out of reach of children
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